Posts
📑 课程：转录组生信实操
虚拟敲除：多组学整合挖掘CKAP2在胃癌中的保护作用
文献《Integrated Single-Cell Virtual Knockout and Machine Learning Analyses Reveal a Protective Role of CKAP2 in Gastric Cancer》思路解析
多组学整合：银屑病乳酸代谢相关标志物SLC25A4挖掘
文献《Integrating bulk RNA-seq, Mendelian randomization and single-cell RNA-seq to elucidate the roles of lactate metabolism related markers-SLC25A4 and keratinocyte in the pathogenesis of psoriasis》思路解析
微生物组：多组学数据挖“菌群-代谢物-基因”致病链条
论文《TMulti-omics integration reveals functional signatures of gut microbiome in atherosclerosis》套路解析
微生物组：16S + 宏基因组 + 网络分析筛选高效石油降解菌
论文《Top-down enrichment of oil-degrading microbial consortia reveals functional streamlining and novel degraders》套路解析
GBD数据库: Joinpoint + ARIMA + BAPC 联合分析中国结核病负担变化及未来趋势预测
论文《Analysis of the trends and predictions of tuberculosis burden in China from 1990 to 2021 based on the GBD database》套路解析
GBD数据库: Joinpoint + SDI 分层 + 风险因素分析全球早发性缺血性心脏病负担变化与趋势预测
论文《Global, regional, and national burden of ischemic heart disease in young and middle-aged population from 1990 to 2021》套路解析
孟德尔随机化(MR)：二甲双胍对原发性肝癌的保护作用及机制挖掘
论文《Mendelian Randomization and Bioinformatics Analysis Reveal the Potential Protective Role of Metformin in Primary Liver Cancer 》套路解析
双向MR+敏感性分析：挖掘血液代谢物与前列腺癌因果关系
论文《Associations between circulating metabolites and pca: a bidirectional two-sample Mendelian randomization study》套路解析